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Parliament voted by 382-128 yesterday in favour of mitochondrial donation techniques allowing the creation of IVF babies with DNA from three people.
Prime Minister David Cameron, Deputy Prime Minister Nick Clegg and Labour leader Ed Miliband voted for the measures after an intense 90-minute debate.
MPs were handed a free vote on the subject as it was an issue of conscience.
Several ministers, including Justice Secretary Chris Grayling and Attorney General Jeremy Wright, voted No. Others, such as Home Secretary Theresa May, stayed away.
Cheers could be heard in the Commons when the vote result was announced.
The Bill still has to be agreed by peers before becoming law but once passed it will mean Britain becomes the first country in the world to legalise the pioneering techniques.
Eighty-one Tories and 31 Labour MPs opposed the measures and calls were made for the debate to be extended to allow more expression of views.
