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Iranian Foreign Minister Mohammad Javad Zarif warned the US that its "wishes are unlikely to come true" in upcoming nuclear talks.
He said Washington wanted Iran to give up major parts of its nuclear programme but that Tehran would not agree to such demands.
The comments may have been in response to Iranian hardliners' criticism that President Hassan Rouhani would give up too much for too little in planned negotiations over a final comprehensive deal.
"America has wishes and those wishes are unlikely to come true and that's why they are negotiating with the Islamic Republic of Iran to achieve a solution based on realities," Mr Zarif told a Tehran news conference.
Iran stopped enriching uranium to 20 per cent - just shy of weapons-grade material - last month after a November deal with six world powers.
Under the six-month deal Iran has agreed to halt its 20 per cent enrichment programme and destroy or dilute its stockpiles of 20 per-cent-enriched uranium.
In return Western powers lifted sanctions on petrochemical products, insurance, gold and other precious metals, the car industry, passenger plane parts and services.
They also promised to release nearly £2.6 billion in blocked Iranian oil assets in eight instalments over the six months. The first £340 million was handed over on February 1, Iranian officials said.
The six-nation group - the five permanent members of the UN security council plus Germany - and Iran are set to begin talks on a permanent deal on February 18.
US officials are pushing to dismantle major parts of Iran's nuclear programme.
US President Barack Obama said in December: "If we could create an option in which Iran eliminated every single nut and bolt of their nuclear programme ... I would take it."
Western politicians have repeatedly claimed that Iran is seeking to build nuclear weapons, piling sanctions on the country as a result.
Tehran has long rejected the suggestion that it wants to enrich uranium to weapons-grade quality.
US intelligence reports consistently suggest that Iran has no intention of building nuclear weapons.
